Advanced glycation end products in degenerative nucleus pulposus with diabetes
نویسندگان
چکیده
منابع مشابه
Advanced glycation end products, dementia, and diabetes.
It is becoming abundantly clear that the insight into the pathological process of Alzheimer’s disease (AD) provided through autosomal dominant variants of the condition is only a partial one. The formation and aggregation of Aβ and the phosphorylation and aggregation of tau are clearly part of the core pathogenesis. However, although these may be necessary processes, and indeed in familial form...
متن کاملAdvanced glycation end products
Aging is the progressive accumulation of damage to an organism over time leading to disease and death. Aging research has been very intensive in the last years aiming at characterizing the pathophysiology of aging and finding possibilities to fight age-related diseases. Various theories of aging have been proposed. In the last years advanced glycation end products (AGEs) have received particula...
متن کاملAdvanced glycation end-products and advanced oxidation protein products in patients with diabetes mellitus.
Accelerated glycoxidation takes part in the development of diabetic complications. We determined advanced glycation end-products (AGEs) and advanced oxidation protein products (AOPP) in the sera of 52 patients with diabetes mellitus (DM) - 18 with DM Type 1 and 34 with DM Type 2 and examined their relationship to the compensation of the disease. AGEs were estimated spectrofluorimetrically (350 ...
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Intervertebral disc degeneration is widely recognized as a cause of lower back pain, neurological dysfunction and other musculoskeletal disorders. The major inflammatory cytokine IL-1β is associated with intervertebral disc degeneration; however, the molecular mechanisms that drive IL-1β production in the intervertebral disc, especially in nucleus pulposus (NP) cells, are unknown. In some tissu...
متن کاملAdvanced glycation end products, diabetes, and the brain.
All since 1951, it is now a weekly with 48 issues per year. Type 2 diabetes is associated with declines in cogni-tion, including learning and memory, mental flexibility , and mental speed. The degree of decrement tends to be modest and evolves slowly as a person ages. However, some patients diagnosed with type 2 diabetes experience a different course, with increased risk of more severe cognitiv...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Research
سال: 2013
ISSN: 0736-0266
DOI: 10.1002/jor.22508